Confirming neuroleptic-resistant schizophrenia

standard’ treatment for treatment-resistant schizophrenia, after failure of two antipsychotics at adequate doses for an adequate duration of time. However, even after 1 year, a number of patients fail to respond to clozapine alone. We question the term ‘treatment-resistant’, which implies that little further can be done and generates therapeutic nihilism, and instead suggest the term ‘neuroleptic-resistant schizophrenia’ as a more positive alternative. In this editorial we suggest a number of treatment options for patients resistant to clozapine monotherapy, and hope to generate a fresh and positive approach.